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Twice daily is common for systemic or severe injuries

& Rahman, A

doi:10.4088/JCP.19m13207 2

AMPK activation during energy deficiency can both inhibit ferroptosis, through phosphorylation of ACACA/ACC (acetyl-CoA carboxylase alpha) in MEFs (mouse embryonic fibroblasts) and human renal adenocarcinoma cells [68], and promote ferroptosis, by targeting BECN1 (beclin1)-mediated system xc - inhibition in human colorectal cancer cells [25] or regulating pyrimidinosome assembly in human cervical cancer cells [69]